Possible Interaction: Arachidonic Acid and Vasoconstrictor Agents

“This attenuated vasoconstrictor response may be linked to altered production of vasoactive arachidonic acid metabolites and reduced muscarinic receptor expression/signaling.”

“A major role for vasodilatory arachidonic acid AA ) metabolites is to modulate the effects of vasoconstrictor stimuli on renal vasculature and sodium excretion; thus, an alteration of this interplay may be responsible for some forms of experimental and human hypertension.”

“These include inadequate production or reduction of bioavailability of nitric oxide, alterations in metabolism of arachidonic acid , resulting in an increase in vasoconstrictors and decrease in vasodilators, and upregulation of endothelin.”

“Although these results do not exclude entirely the possibility that the lack of antihypertensive effect of arachidonic acid may be due, in part, to the concomitant formation of vasoconstrictor prostanoids , they do not support it.”

“Pretreatment of cells with exogenous arachidonic acid (10(-5) M) abolished their responsiveness to subsequent stimulation by arachidonic acid or vasoactive agents , but not PGH2.”

“This arachidonic acid analog exerted a coronary vasodilator effect and significantly antagonized the coronary vasoconstrictor effect of LTD4.”

“Since the vasoconstrictor responses to renal nerve stimulation were enhanced by the blockade of PG synthesis and were reduced by stimulation of PG synthesis with arachidonic acid , this suggests that PGE2 functions as an inhibitory modulator of the adrenergic nervous system.”

“ Arachidonic acid inhibited the vasoconstrictor responses to sympathetic nerve stimulation in the rabbit kidney, but in the rat kidney it caused augmentation of these responses.”