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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Arachidonic Acid and Triclosan

Research Papers that Mention the Interaction

Addition of exogenous unlabelled arachidonic acid (AA) to the cells resulted in enhanced PGE2 formation which was reduced by triclosan.
The upregulation of the metabolism of AA to PGE2 induced by IL-1beta, was markedly reduced in the presence of triclosan.
Journal of clinical periodontology  •  1996  |  View Paper
Triclosan also inhibited 5-lipoxygenase with an IC-50 of 43 microM. The 15-lipoxygenase was similarly inhibited by triclosan with an IC-50 of 61 microM. Hence, triclosan has the ability to inhibit both the cyclo-oxygenase and lipoxygenase pathways of arachidonic acid metabolism with similar efficacy.
Journal of clinical periodontology  •  1995  |  View Paper