Possible Interaction: Arachidonic Acid and Trapidil

“These results show that trapidil increased arachidonic acid mobilization in the platelets.”

“Thrombin stimulation following the addition of trapidil resulted in an increase in stearic acid and a decrease in arachidonic acid , compared with the trapidil-free control samples (stearic acid, P < 0.05; arachidonic acid, P < 0.02).”

“ Trapidil prevented completely the effects of exogenous arachidonic acid and of U46619 on interaction of thrombocytes and the substrate but inhibited only by 40-50% the synthesis of thromboxane A2 in the cells induced by arachidonic acid.”

“ Trapidil (N,N‐diethyl‐5‐methyl[l,2,4]triazolo[l,5‐α]pyrimidine‐7‐amine) inhibits platelet spreading and aggregation induced by arachidonic acid (AA), a stable analogue of prostaglandin (PG) endoperoxides (U46619), ADP, and low concentrations of thrombin, but not by A23187 and high concentrations of thrombin.”

“ Trapidil completely prevents the effects of the exogenous AA and U46619 on platelet-substrate interactions, but inhibits the AA-stimulated synthesis of thromboxane A2 (TXA2) in platelets by 40-50% only.”

“This action … that trapidil at concentrations ranging from 139 microM … of platelet aggregation induced by ADP, arachidonic acid , thrombin or thromboxane A2 mixture, inhibition of platelet release reaction induced by ADP, arachidonic acid or … rabbit platelets by arachidonic acid and potentiating action on antiaggregatory action of prostacyclin in vitro.”

“ Trapidil and aspirin protected only against rabbit platelet aggregation as induced by arachidonic acid.”