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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Tranylcypromine
Research Papers that Mention the Interaction
“In this work we demonstrate that phenelzine and tranylcypromine have an inhibitory effect on the production of 2-series prostaglandins derived from arachidonic acid , and possibly a similar effect on prostaglandins of the 1-series derived from dihomo-gamma-linolenic acid.”
The influence of phenelzine and tranylcypromine on the release of prostaglandins from the rat mesenteric vascular bed.“The cyclooxygenase inhibitors--indomethacin, aspirin, and eicosatetraynoic acid--and a prostacyclin synthetase inhibitor, tranylcypromine , also significantly reduced or eliminated the vasodilator effect of arachidonic acid.”
“Indomethacin (n=4) and acetylsalicylic acid (n=4) (prostaglandin (PG) synthesis inhibitors), and tranylcypromine (n=4) (a PGI2 synthetase inhibitor), prevented the cyclic AMP increases from arachidonic acid.”
“We conclude that tranylcypromine and 15-hydroperoxyarachidonate not only inhibit prostacyclin synthesis but also affect other steps in the metabolism of arachidonic acid in whole cells.”
“ tranylcypromine and 15-hydroperoxy arachidonic acid (HP-AA), antagonized cAMP elevations caused by arachidonic acid , suggesting that PGI2 might be involved.”
“ Tranylcypromine 500 microgram/ml also inhibited contractions to arachidonic acid.”
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