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Last Updated: 3 years ago
supplement:
Arachidonic Acid
Research Papers that Mention the Interaction
“The phorbol ester TPA significantly increased [3H]arachidonic acid release as well as PGE2 formation in hepatocytes in line with known effects in other cell types.”
Stimulation of DNA synthesis by tumor promoters in primary rat hepatocytes is not mediated by arachidonic acid metabolites“By contrast, a potent PKC activator, TPA , abolished the initial component of the currents and arachidonic acid enhanced this effect.”
“After a 24‐hr incubation with 0.1 μM TPA or 1.0 μM A23187, arachidonic acid elicited significantly more PGE2, synthesis in agonist‐treated cells than it did in control cells in primary culture.”
“The release of arachidonic acid from prelabelled cells was stimulated by TPA and the diacylglycerols even in the presence of an inhibitor of reacylation, indicating an activation of phospholipase A2.”
“Combined treatment with AA and LHRH or AA plus TPA showed additive effects on P formation.”
“Likewise, addition of AA partially antagonized the inhibitory effect of 12-O-tetradecanoylphorbol-13-acetate ( TPA ; 10(-9) M) on FSH-induced P production (by 71%).”
“In the rat liver cells that had been prelabeled with [3H]arachidonic acid, the release of 6-keto-PGF1 alpha and arachidonic acid also was stimulated by the IL 1, and this release was synergistic in the presence of TPA.”
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