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Discover Supplement-Drug Interactions

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Last Updated: 5 days ago

Possible Interaction: Arachidonic Acid and Ticlopidine

Research Papers that Mention the Interaction

Exercise produced a statistically significant increase in platelet activation, while Ticlopidine significantly inhibited the platelet aggregation induced by ADP, AA and collagen as well as circulating aggregates both at rest and after the exercise test.
Minerva medica  •  1990  |  View Paper
Collagen- and arachidonic acid-induced platelet aggregation was all inhibited by CS, TP and ASA.
Arzneimittel-Forschung  •  1987  |  View Paper
We found the following: ticlopidine significantly (P less than 0.001) prolonged the skin bleeding time and impaired the binding of radiolabeled fibrinogen and von Willebrand Factor, the clot retraction and the aggregation of platelets in response to ADP, epinephrine, thrombin, ionophore A23187, collagen, or arachidonic acid.
The Journal of clinical investigation  •  1985  |  View Paper
Studies in animals and man have demonstrated that ticlopidine is a potent inhibitor of platelet aggregation induced by adenosine diphosphate (ADP), and variably inhibits aggregation due to collagen, adrenaline (epinephrine), arachidonic acid , thrombin, and platelet activating factor.
Drugs  •  1987  |  View Paper
On the other hand, upon incubation of non-labelled platelets with [ 14 C]-AA, ticlopidine impairs the incorporation of AA into all platelet phospholipids under conditions which are no longer lytic for the cells.
Biochemical pharmacology  •  1981  |  View Paper
Ticlopidine administration during 3 days leads to an increase in the amounts of TxB2, PGE2, HHT and the unknown metabolite and a decrease in that of AA dependent on the dose administered.
Agents and Actions  •  2005  |  View Paper