Possible Interaction: Arachidonic Acid and Ticlopidine

“Exercise produced a statistically significant increase in platelet activation, while Ticlopidine significantly inhibited the platelet aggregation induced by ADP, AA and collagen as well as circulating aggregates both at rest and after the exercise test.”

“Collagen- and arachidonic acid-induced platelet aggregation was all inhibited by CS, TP and ASA.”

“We found the following: ticlopidine significantly (P less than 0.001) prolonged the skin bleeding time and impaired the binding of radiolabeled fibrinogen and von Willebrand Factor, the clot retraction and the aggregation of platelets in response to ADP, epinephrine, thrombin, ionophore A23187, collagen, or arachidonic acid.”

“Studies in animals and man have demonstrated that ticlopidine is a potent inhibitor of platelet aggregation induced by adenosine diphosphate (ADP), and variably inhibits aggregation due to collagen, adrenaline (epinephrine), arachidonic acid , thrombin, and platelet activating factor.”

“On the other hand, upon incubation of non-labelled platelets with [ 14 C]-AA, ticlopidine impairs the incorporation of AA into all platelet phospholipids under conditions which are no longer lytic for the cells.”

“ Ticlopidine administration during 3 days leads to an increase in the amounts of TxB2, PGE2, HHT and the unknown metabolite and a decrease in that of AA dependent on the dose administered.”