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Last Updated: 3 years ago
supplement:
Arachidonic Acid
Research Papers that Mention the Interaction
“However, the treatment of cells with EGTA, arachidonic acid and H-7 (300 microM), a potent inhibitor of protein kinase C (PKC), almost completely suppressed the activity of TRH for sustained PRL secretion.”
Ca2(+)-independent secretory mechanism of thyrotropin-releasing hormone (TRH) involves protein kinase C in rat pituitary cells.“In this study, we further characterize the effects of arachidonic acid on Ca2+ homeostasis in GH3 cells and demonstrate its antagonism of changes induced by thyrotropin-releasing hormone (TRH).”
“… arachidonic acid, TRH stimulated prolactin secretion to only 2.6 +/- 0.3 ng/10(6) cells/min between 0 and 2 min and to 3.2 +/- … to 10 min; these values are not different from each other nor from the response between 2 and 10 min in control cells.”
“In cells prelabeled with [3H]arachidonic acid, A23187, but not TRH , increased unesterified [3H]arachidonic acid to 166 +/- 8% of control.”
“In cells labeled to isotopic steady … with [3H]arachidonic acid, TRH stimulated a … in free [3H]arachidonic acid to 210 +/- 8% of the control value at 15 sec (P less than 0.001), with a return to a level of 125 +/- 2% of the control value by 5 min.”
“ TRH stimulated the metabolism of lipids of the phosphatidylinositol (PI)-phosphatidic acid (PA) cycle and caused an increase in the level of free or unesterified arachidonic acid in mouse pituitary thyrotropic tumor (TtT) cells.”
“ Arachidonic acid , a prostanoid precursor, increased the amount of TSH released by TRH.”
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