Possible Interaction: Arachidonic Acid and Theophylline

“MIX inhibited the formation of lysophospholipids, 1,2-diacylglycerol and phosphatidic acid in bradykinin-stimulated pig endothelial cells, suggesting that … inhibition of prostacyclin synthesis resulted from an apparent inhibition of both phospholipase A2 and phospholipase C. Other phosphodiesterase inhibitors, theophylline and mopidamole, also raised … levels and inhibited arachidonic acid ….”

“ Theophylline also inhibited arachidonic acid-stimulated platelet aggregation suggesting an effect on cyclooxygenase activity.”

“In human liver microsomes, arachidonic acid inhibited CYP1A2-dependent theophylline hydroxylation , CYP2C8-dependent taxol 6alpha-hydroxylation and CYP2C19-dependent omeprazole 5-hydroxylation.”

“In addition, exogenous arachidonic acid concentration‐dependently (0.3 μm‐3 μm) reversed the inhibition of LTC4 synthesis by the PDE inhibitors, indicating that theophylline and rolipram suppress the mobilization of arachidonic acid.”

“ Theophylline is known to interfere with histamine release from mast cells, mediator release of arachidonic acid metabolites, the cyclic AMP concentration and suppressor cell activity.”

“Hispidulin, a natural flavone, and theophylline inhibited platelet aggregation triggered by adenosine-5'-monophosphate, arachidonic acid , paf-acether and collagen.”

“LA 2851 and theophylline , using a superfused lung preparation, were found ineffective on the synthesis of cyclooxygenase products from arachidonic acid.”