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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
supplement:
Tannins
Research Papers that Mention the Interaction
“At slightly higher concentrations, tannin promotes the dose-dependent release of arachidonic acid from the macrophage membranes (EC50 = 65 micrograms/mL), which could also contribute to the local inflammatory reaction.”
Cotton condensed tannin: a potent modulator of alveolar macrophage host-defense function.“The release of AA from EC was markedly inhibited either by scavengers of H2O2, by proteinase inhibitors, by cationic agents,by HClO, by tannic acid , and by quinacrin.”
“Both beta-glucan and tannin stimulated acyl turnover, especially arachidonic acid turnover, in these and other lipid classes by a factor of 2 or more.”
“Earlier work had shown that these agonists exhibit different effects on arachidonate liberation and release, and that only tannin inhibits the uptake and incorporation of exogenous arachidonic acid , suggesting inhibition of reacylation.”
“In the present study, we demonstrate that condensed tannin also alters arachidonic acid (C20:4) metabolism in these cells.”
Condensed tannin promotes the release of arachidonic acid from rabbit resident alveolar macrophages.
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