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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Suprofen
Research Papers that Mention the Interaction
“ Suprofen appears to exert its pharmacological effect by inhibiting synthesis of prostaglandins from precursor arachidonic acid , inhibiting the pain induced by bradykinin, and by raising the threshold to pain induced by prostaglandins.”
Introduction to the pharmacology of suprofen.“Platelet aggregation induced by collagen, adrenaline and arachidonic acid was inhibited by suprofen depending on its concentration.”
“ Suprofen is markedly more potent inhibiting the conversion of arachidonic acid to PGF2 alpha than is ibuprofen (30 times) or aspirin (1250 times).”
“Taken together with the important role … (Hahn et al., 1982) that suprofen is more potent and effective than a number of … in vivo guinea pig uterine contractions induced by arachidonic acid , the results of the present study suggest a mechanism … effective treatment for the signs and symptoms of dysmenorrhea.”
Potent and selective effects of suprofen on uterine prostaglandin synthesis.“Experiments in mice have shown that suprofen antagonizes abdominal stretching induced by the physiological precursor of PG release, arachidonic acid (ED50 = 0.07 mg/kg, p.o.),”
“Recent experiments have shown that suprofen inhibits uterine hyperactivity induced by the physiological substances, arachidonic acid , bradykinin (BK) and PGF2 alpha.”
“ Suprofen also strongly inhibited malondialdehyde formation by guinea-pig platelets incubated with arachidonic acid.”
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