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Last Updated: 8 months ago

Possible Interaction: Arachidonic Acid and Suprofen


Arachidonic Acid

Research Papers that Mention the Interaction

Suprofen appears to exert its pharmacological effect by inhibiting synthesis of prostaglandins from precursor arachidonic acid , inhibiting the pain induced by bradykinin, and by raising the threshold to pain induced by prostaglandins.
Pharmacology  •  1983  |  View Paper
Platelet aggregation induced by collagen, adrenaline and arachidonic acid was inhibited by suprofen depending on its concentration.
Archives internationales de pharmacodynamie et de therapie  •  1975  |  View Paper
Suprofen is markedly more potent inhibiting the conversion of arachidonic acid to PGF2 alpha than is ibuprofen (30 times) or aspirin (1250 times).
Taken together with the important role … (Hahn et al., 1982) that suprofen is more potent and effective than a number of … in vivo guinea pig uterine contractions induced by arachidonic acid , the results of the present study suggest a mechanism … effective treatment for the signs and symptoms of dysmenorrhea.
Prostaglandins, leukotrienes, and medicine  •  1985  |  View Paper
Experiments in mice have shown that suprofen antagonizes abdominal stretching induced by the physiological precursor of PG release, arachidonic acid (ED50 = 0.07 mg/kg, p.o.),
Recent experiments have shown that suprofen inhibits uterine hyperactivity induced by the physiological substances, arachidonic acid , bradykinin (BK) and PGF2 alpha.
Prostaglandins  •  1984  |  View Paper
Suprofen also strongly inhibited malondialdehyde formation by guinea-pig platelets incubated with arachidonic acid.
Archives internationales de pharmacodynamie et de therapie  •  1976  |  View Paper