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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Sulindac
Research Papers that Mention the Interaction
“Importantly, when measured in the presence of arachidonic acid , the reduction in the levels of all 5 prostanoids due to sulindac was statistically correlated with a reduction in the size and number of adenomas in the two groups of patients combined.”
“In the latter patients, arachidonic acid also augmented the inhibition of prostanoid synthesis by sulindac.”
Tissue prostanoids as biomarkers for chemoprevention of colorectal neoplasia: correlation between prostanoid synthesis and clinical response in familial adenomatous polyposis.“When sulindac was added to the arachidonic acid-supplemented diet, tumor number was reduced by 82%, whereas eicosanoid levels remained elevated.”
Sulindac causes rapid regression of preexisting tumors in Min/+ mice independent of prostaglandin biosynthesis.“Indomethacin, oxamethacin and sulindac inhibit the action of arachidonic acid on the rat stomach strips in vitro.”
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