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Possible Interaction: Arachidonic Acid and Sulfinpyrazone

Research Papers that Mention the Interaction

Sulfinpyrazone (100 microM) and its thioether metabolite G25671 (50 microM) suppressed arachidonic acid-induced platelet aggregation, thromboxane (Tx) B2 formation and ATP release.
We now demonstrate that the presence of sulfinpyrazone or G25671 during platelet exposure to arachidonic acid or U46619 prevented desensitization.
The Journal of pharmacology and experimental therapeutics  •  1987  |  View Paper
4 Short infusions of acetylsalicylic acid at low concentrations (2.9 μg/ml), dipyridamole (0.6 μg/ml) and sulphinpyrazone (28.7 μg/ml) selectively inhibited the vasoconstrictor phase of the response to AA.
British journal of pharmacology  •  1982  |  View Paper
The present study indicates that the pulmonary metabolism of arachidonic acid is changed only slightly by sulfinpyrazone.
Pharmacology  •  1982  |  View Paper
In contrast, bronchoconstriction and thrombocytopenia in vivo, as well as platelet aggregation and the release reaction ex vivo and in vitro, induced by arachidonic acid (AA), were suppressed by sulphinpyrazone.
European journal of pharmacology  •  1982  |  View Paper
Similar findings have been presented by Butler et a1 (1979) who found the inhibitory effect on arachidonic acid-induced platelet aggregation in guinea-pigs was greater 7 h than 1 h after oral administration of sulphinpyrazone.
The Journal of pharmacy and pharmacology  •  1980  |  View Paper
Both sulfinpyrazone and ibuprofen caused a dose-related reduction in flow increment after arachidonic acid.
Sulfinpyrazone , ≥10 mg/kg, and ibuprofen, ≥1 mg/kg, produced a mean reduction of least 60% (p < 0.02 for each) in the vasodilator response to 1 mg arachidonic acid.
Journal of cardiovascular pharmacology  •  1980  |  View Paper