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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Sulfinpyrazone
Research Papers that Mention the Interaction
“ Sulfinpyrazone (100 microM) and its thioether metabolite G25671 (50 microM) suppressed arachidonic acid-induced platelet aggregation, thromboxane (Tx) B2 formation and ATP release.”
“We now demonstrate that the presence of sulfinpyrazone or G25671 during platelet exposure to arachidonic acid or U46619 prevented desensitization.”
Effects of sulfinpyrazone and its metabolite G25671 on platelet activation and desensitization and on bronchoconstriction induced by the prostaglandin endoperoxide analog U46619.“4 Short infusions of acetylsalicylic acid at low concentrations (2.9 μg/ml), dipyridamole (0.6 μg/ml) and sulphinpyrazone (28.7 μg/ml) selectively inhibited the vasoconstrictor phase of the response to AA.”
CORONARY VASOCONSTRICTOR AND VASODILATOR ACTIONS OF ARACHIDONIC ACID IN THE ISOLATED PERFUSED HEART OF THE RAT“The present study indicates that the pulmonary metabolism of arachidonic acid is changed only slightly by sulfinpyrazone.”
“In contrast, bronchoconstriction and thrombocytopenia in vivo, as well as platelet aggregation and the release reaction ex vivo and in vitro, induced by arachidonic acid (AA), were suppressed by sulphinpyrazone.”
“Similar findings have been presented by Butler et a1 (1979) who found the inhibitory effect on arachidonic acid-induced platelet aggregation in guinea-pigs was greater 7 h than 1 h after oral administration of sulphinpyrazone.”
“Both sulfinpyrazone and ibuprofen caused a dose-related reduction in flow increment after arachidonic acid.”
“ Sulfinpyrazone , ≥10 mg/kg, and ibuprofen, ≥1 mg/kg, produced a mean reduction of least 60% (p < 0.02 for each) in the vasodilator response to 1 mg arachidonic acid.”
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