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Last Updated: 3 years ago

Possible Interaction: Arachidonic Acid and Steroids

supplement:

Arachidonic Acid

Research Papers that Mention the Interaction

The steroid significantly reduced the erythema induced by topical arachidonic acid , intradermal histamine, and compound 48/80.
Archives of dermatology  •  1986  |  View Paper
Pulsed steroids have nongenomic actions not seen with low-dose steroids, including rapid inhibition of arachidonic acid release and of calcium and sodium cycling across plasma membranes of immune cells.
Archives of neurology  •  2008  |  View Paper
As a consequence of their modulation of arachidonic acid uptake and its distribution into hOB cellular phospholipids, steroids might alter the biological effects of other hormones whose actions include the stimulated production of bioactive AA metabolites, such as prostaglandins or the various lipoxygenase products.
Journal of cellular biochemistry  •  1995  |  View Paper
Thus, topical steroids act early in the inflammatory pathway by preventing the initial release of arachidonic acid.
International journal of dermatology  •  1987  |  View Paper
The accumulation of arachidonic acid in the medium after steroid treatment was associated with a significant inhibition of cell acyltransferase activity, suggesting that steroids may also act upon arachidonic acid metabolism at sites other than those of phospholipase activity.
Biochimica et biophysica acta  •  1986  |  View Paper
We suggest that the inhibitory action of steroids on arachidonic acid metabolite in human lung fragments contributes to their therapeutic efficacy in pulmonary diseases.
Journal of immunology  •  1986  |  View Paper
Significant reductions in AA and LTB4 were observed at 72 h in steroid treated lesions.
British journal of clinical pharmacology  •  1986  |  View Paper
Steroids reduce arachidonic acid metabolism by inhibiting the release of substrate for cyclo-oxygenase and lipoxygenase activity.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde  •  1984  |  View Paper
Arachidonic acid overcame the inhibitory effect of hydrocortisone on PGE production, but failed to restore IFN production in the presence of the steroid.
The Journal of general virology  •  1982  |  View Paper
6 These results provide direct evidence that steroids inhibit prostaglandin formation by blocking evoked rise in the concentration of free arachidonic acid.
British journal of clinical pharmacology  •  1982  |  View Paper
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