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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Somatostatin
Research Papers that Mention the Interaction
“In both cell lines, SSTR are functional since SRIF inhibits cyclic AMP pathway, stimulates arachidonic acid release and enhances cell proliferation.”
Somatostatin as a regulator of first-trimester human trophoblast functions.“Very low concentrations of somatostatin (S-14) strongly potentiate the in vitro aggregation induced by collagen, ristocetin and arachidonic acid , but not that induced by ADP or epinephrine, in both human platelet rich plasmas and gel-filtered platelet preparations.”
“In addition, sst1 and sst2 receptors are both coupled to a decrease of arachidonic acid (AA) release with an efficacy similar to that of SRIF, suggesting that SRIF reduces AA release through either a partial activation of both receptors or the activation of one at a time.”
Somatostatin (SRIF) modulates distinct signaling pathways in rat pituitary tumor cells; negative coupling of SRIF receptor subtypes 1 and 2 to arachidonic acid release“Furthermore, external addition of arachidonic acid increased somatostatin secretion.”
“The transformation of arachidonic acid to active lipoxygenase metabolites was suppressed by somatostatin (10(-9) and 10(-8) M).”
“ Arachidonic acid (AA) stimulates the in vitro release of somatostatin (SRIF) from the hypothalamic median eminence (ME).”
“The results suggest that these "epoxygenase" metabolites of AA may be physiologically involved in the control of SRIF release.”
“External addition of arachidonic acid increased the release of somatostatin , whereas E2 and F2α prostaglandins had no effect.”
Phospholipase A2 and Somatostatin Release are Activated in Response to N‐Methyl‐D‐Aspartate Receptor Stimulation in Hypothalamic Neurons in Primary Culture
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