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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Sodium Fluoride
Research Papers that Mention the Interaction
“Inactivation of LTB4 by the neutrophils via omega-oxidation into 20-hydroxy-LTB4 and …-carboxy-LTB4 is inhibited by NaF. In combination with other cell stimuli, NaF showed modulatory effects, such as an enhanced formation … the leukotrienes when FMLP, opsonized zymosan, PMA, and arachidonic acid were applied as stimuli.”
Effect of sodium fluoride on the generation of lipoxygenase products from human polymorphonuclear granulocytes, mononuclear cells and platelets--indication for the involvement of G proteins.“PGH2 analog (10−4M) and arachidonic acid (10−4M) both inhibited to a similar extent adenylate cyclase stimulated by histamine or by NaF , but not that stimulated by PGE2 or by Gpp(NH)p.”
Inhibition of histamine-sensitive adenylate cyclase from guinea pig fundic gastric mucosa by arachidonic acid and by an analog of prostaglandin endoperoxide PGH2“ NaF , a nonselective activator of heterotrimeric guanine nucleotide-binding proteins (G proteins), increased the release of arachidonic acid (AA) and prostacyclin (PGI2) production in bovine aortic endothelial cells (BAEC) at low concentrations (40-60 mM).”
“Moreover, GTP and its non-hydrolysable analogs GTP gamma S and GppNHp and also NaF additionally increase the carbachol-mediated liberation of AA from PI.”
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