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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Arachidonic Acid and Simvastatin

Research Papers that Mention the Interaction

Treatment with simvastatin was associated with an increase in the arachidonic acid content of the erythrocyte membrane from 12.2 to 15.3 mole% (P < 0.05).
Clinica chimica acta; international journal of clinical chemistry  •  1996  |  View Paper
Simvastatin decreased proportions from total fatty acids of palmitic acid by 2.0% (P<0.01), linoleic acid (C18:2n-6) by …:3n-6) by 11.1% (P<0.001), dihomo-&ggr;-linolenic acid (C20:3n-6) by 4.2% (P<0.01), arachidonic acid (C20:4n-…<0.001).
Arteriosclerosis, thrombosis, and vascular biology  •  2005  |  View Paper
In THP-1 cells, simvastatin decreases, in a concentration-dependent manner, cholesterol synthesis and increases linoleic acid (LA) conversion to its long-chain derivatives, in particular to arachidonic acid , activating Δ6 and Δ5 fatty acid (FA) desaturases.
Lipids  •  2003  |  View Paper
Simvastatin enhances the conversion of linoleic acid to their long chain polyunsaturated fatty acid derivatives, e.g. arachidonic acid , in addition to typically inhibiting the de novo cholesterol synthesis, in cultured cells.
European journal of pharmacology  •  2003  |  View Paper
In view of the multiple biologic properties of AA, the AA released as a result of the action of the statins may play a role in some of the pharmacological effects attributed to these drugs.
Lipids in Health and Disease  •  2003  |  View Paper