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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Salicylic Acid
Research Papers that Mention the Interaction
“ Salicylate blocked this translocation, which may contribute to the enhancement of AA toxicity by salicylate.”
Role of p38 MAPK in CYP2E1-dependent Arachidonic Acid Toxicity*“This effect seems to be prevented in the presence of high concentrations of arachidonic acid , which has been shown to interfere with inhibition by salicylate of cyclooxygenase-2-mediated prostanoid formation in vitro.”
“Salicylate alone was not toxic, and the enhanced toxicity by AA in the presence of salicylate was prevented by diallyl sulfide, a CYP2E1 inhibitor, and by the antioxidant (+/-)6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid.”
“ Salicylate also potentiated AA toxicity in hepatocytes isolated from pyrazole treated rats with high levels of CYP2E1 and from saline controls.”
“Salicylates and NSAIDs inhibit PG-forming cyclooxygenase, and recent studies suggest that abnormal levels of arachidonic acid metabolites consisting of decreased PGs and increased LTs may mediate salicylate ototoxicity.”
“Exposure of neutrophils to aspirin or sodium salicylate (poor COX inhibitor) inhibited Erk activity and adhesiveness of formylmethionyl-leucyl-phenylalanine- and arachidonic acid-stimulated neutrophils, consistent with anti-inflammation but not COX inhibition (IC50s = 1-8 mM).”
“ Sodium salicylate acutely (30 min) also caused a concentration-dependent inhibition of COX-2 activity measured in the presence of 0, 1, or 10 microM exogenous arachidonic acid.”
“ VS significantly inhibited the arachidonic acid ear oedema after lh at doses of 1.5-45 micrograms per ear; however, only at the dose of 45 micrograms per ear was it able to significantly reduce the croton oil-induced oedema at 6h.”
Effects of valeryl salicylate, a COX-1 inhibitor, on models of acute inflammation in mice.“ AA caused toxicity that was increased by sodium salicylate.”
“We studied the ability of 2-hydroxybenzoic acid analogues to block ASA and to prevent the platelet desensitization due to a first exposure to AA.”
“The enhancement of insulin release by arachidonic acid was completely inhibited by the cyclooxygenase inhibitor, sodium salicylate (0.5 mg/ml).”
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