Possible Interaction: Arachidonic Acid and Rabbit Allergenic Extract

“In preliminary tests, they selectively inhibited rabbit platelet aggregation induced by arachidonic acid.”

“Arachidonic acid AA ) inhibited 86Rb uptake in a dose-dependent manner in rabbit medullary tubules representing the thick ascending limb of the loop of Henle (mTALH).”

“The addition of fMet-Leu-Phe, leukotriene B4, or arachidonic acid to rabbit neutrophils causes a rise in the level of intracellular free calcium as measured by the fluorescent dye quin-2.”

“ Arachidonic acid , therefore, in addition to its well‐described agonist properties, also possesses antagonist activities toward rabbit neutrophils.”

“Inhibition of the arachidonic acid cascade at various levels affects the relaxing action of acetylcholine ( rabbit aorta and dog common carotid artery) while being inactive against both the relaxing (dog common carotid artery) and contractile actions (rabbit aorta, rabbit jugular and mesenteric veins) of bradykinin and des-Arg9-BK.”

“In recent in vitro studies, we have shown that addition of arachidonic acid (K 1/2 congruent to 10(-6) M) also stimulates secretion, cAMP accumulation, and PGE2 production in rabbit ileal mucosa.”

“ Arachidonic acid , a PG precursor, reduced tbe vasoconstrictor responses to sympathetic nerve stimulation and to injected norepinephrine in rabbit , whereas in rat, potentiation of tbe responses to adrenergic stimuli occurred.”

“ Arachidonic acid inhibited the vasoconstrictor responses to sympathetic nerve stimulation in the rabbit kidney, but in the rat kidney it caused augmentation of these responses.”