Possible Interaction: Arachidonic Acid and Quinacrine

“Conversely, the phospholipase A2 inhibitor quinacrine (100 μM) blocked the release of arachidonic acid and PGE2 without affecting the NKA-stimulated formation of IP3.”

“ Quinacrine , which inhibits the liberation of arachidonic acid from phospholipids, also blocks the formation of lysophosphatidylinositol.”

“The liberation of arachidonic acid from membrane‐bound phospholipids, induced by the enzyme phospholipase A2, may be inhibited by mepacrine and the steroidal anti‐inflammatory agents.”

“Supplementation with arachidonic acid (AA) sustained caspase-3 activation induced by QU.”

“In the presence of either quinacrine , an inhibitor of PLA2 pathway activation, or neomycin, which binds to PI mono- and biphosphate thus blocking their degradation by phospholipases, AA and PGE2 secretion were reduced in a dose-dependent manner.”

“The production of arachidonic acid is not inhibited by neomycin, a PI-cycle inhibitor, but is completely abolished by mepacrine , an inhibitor of both phospholipase A2 and C. At low concentration of fluoroaluminate (10 mM NaF) phospholipase A2 but not phospholipase C is activated.”

“The aggregation of human platelets induced by Et3PbCl was inhibited by three different drugs: acetylsalicylic acid, forskolin and quinacrine; but only quinacrine could prevent the liberation of arachidonic acid and the appearance of its metabolites.”

“ Mepacrine , at this concentration, also blocked thrombin-induced phosphorylation of platelet myosin light chain and a 47 kDa protein, thrombin-induced secretion and thrombin-induced release of arachidonic acid from platelet phospholipids.”

“Finally, isobutylmethylxanthine and quinacrine , inhibitors of phosphatidylinositol turnover, inhibit both arachidonic acid generation and phagocytosis, indicating a function for this pathway during this process.”

“This same amount of PI is converted to PA even in the presence of 1 mM quinacrine , which completely inhibits the release of arachidonic acid from phospholipids and which reduces by two-thirds the loss of labeled PI.”