Possible Interaction: Arachidonic Acid and Quercetin

“ Quercetin and naringenin, amongst other flavonoids, are known for their anti-inflammatory activity by modulation of enzymes of the arachidonic acid cascade.”

“On the other hand, the superoxide generation induced by arachidonic acid was markedly suppressed by quercetin.”

“Phenidone, nordihydroguaiaretic acid, quercetin , silybin, phenylthiazolyl-thiourea, and aminotriazole inhibit both luminescence signals promoted by arachidonic acid.”

“All of the drugs caused a dose-related inhibition of increased oxygen consumption by soybean 15-lipoxygenase in the presence of arachidonic acid and the rank order of potency was phenidone ≥ BW755c > ETYA > quercetin > NDGA > indomethacin.”

“Here we show that long-term incubation with quercetin markedly stimulates Ca(2+)-triggered exocytosis and release of AA from the RBL-2H3 cells.”

“The above cascade of reactions, including release of arachidonic acid , was inhibited by 50% with approximately 5 microM quercetin , whereas secretion was inhibited only at higher concentrations of inhibitor.”

“12‐Hydroxyeicosatetraenoic acid (12‐HETE) production from arachidonic acid by cerebral microvessels isolated from perfused adult murine brain was reduced by the lipoxygenase inhibitors baicalein, esculetin, gossypol, nordihydroguaiaretic acid, and quercetin.”

“The release of arachidonic acid in the vitro assay was inhibited in a dose‐dependent manner by nordihydroguaiaretic acid and quercetin that are also potent inhibitors of the mobilization of arachidonic acid in intact macrophages.”

“Other inhibitors of neutrophil response such as quercetin and cytocholasin A have been found to inhibit the metabolism of exogenous arachidonic acid [4].”

“ Quercetine also increases the hypotensive action of arachidonic acid.”