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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Pyrilamine
Research Papers that Mention the Interaction
“In contrast to indometacin which only blocked PG release, mepyramine significantly reduced the histamine-stimulated release of arachidonic acid , too.5.The results show that in the peripheral vascular bed, histamine, via H1-receptors, activates a phospholipase A2 mainly by increasing a transfer of extracellular calcium into the cell.”
Histamine-Induced release of arachidonic acid and of prostaglandins in the peripheral vascular bed“ Mepyramine , promethazine, phentolamine, and clozapine inhibited the aggregations evoked by collagen and AA , but failed to inhibit the ADP-induced aggregation.”
“ Arachidonic acid may owe some of its permeability increasing effects to histamine release, since its effects were also reduced by the anti-histamine, pyrilamine (2.5 mg/kg, i.v.).”
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