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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Arachidonic Acid and Prostaglandin D2

Research Papers that Mention the Interaction

Prestimulation of … with arachidonic acid (10 μM) or human eotaxin (…) also enhanced HQL-79–sensitive PGD2 synthesis, which, by acting on membrane-expressed specific receptors (D prostanoid receptors 1 and 2), displayed an …/paracrine ability to trigger leukotriene C4 synthesis and lipid body biogenesis, hallmark events of eosinophil activation.
The Journal of Immunology  •  2011  |  View Paper
6 In unstimulated cells the proportional formation of PGD2 was overestimated when exogenous arachidonic acid was substrate.
British journal of pharmacology  •  1985  |  View Paper
The endoperoxide analogs PGF2a and PGD2 increase lung resistance and decrease dynamic compliance like arachidonic acid (3).
Advances in experimental medicine and biology  •  1984  |  View Paper
Evidence for enhanced production of prostaglandin D2 was also provided by the rise in the patient's platelet cyclic AMP levels following stimulation with arachidonic acid.
British journal of haematology  •  1981  |  View Paper
The threshold inhibitory effects of PGD2 , PGE1 and PGI2 could be overcome by increasing the concentrations of the aggregating agents AA , collagen or ADP.
British journal of haematology  •  1979  |  View Paper
Moreover, ARA administration significantly increased the plasma levels of ARA, prostaglandin (PG) E2, and PGD2.
Nutrients  •  2013  |  View Paper
Prior addition of either PGE2 (2.8 × 10−10 M) or arachidonic acid (2.8 × 10−7 M) inhibited or reversed various actions of PGD2 on the heart.
Canadian journal of physiology and pharmacology  •  1979  |  View Paper