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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Prostaglandin D2
Research Papers that Mention the Interaction
“Prestimulation of … with arachidonic acid (10 μM) or human eotaxin (…) also enhanced HQL-79–sensitive PGD2 synthesis, which, by acting on membrane-expressed specific receptors (D prostanoid receptors 1 and 2), displayed an …/paracrine ability to trigger leukotriene C4 synthesis and lipid body biogenesis, hallmark events of eosinophil activation.”
Eosinophils as a Novel Cell Source of Prostaglandin D2: Autocrine Role in Allergic Inflammation“6 In unstimulated cells the proportional formation of PGD2 was overestimated when exogenous arachidonic acid was substrate.”
“The endoperoxide analogs PGF2a and PGD2 increase lung resistance and decrease dynamic compliance like arachidonic acid (3).”
“Evidence for enhanced production of prostaglandin D2 was also provided by the rise in the patient's platelet cyclic AMP levels following stimulation with arachidonic acid.”
“The threshold inhibitory effects of PGD2 , PGE1 and PGI2 could be overcome by increasing the concentrations of the aggregating agents AA , collagen or ADP.”
“Moreover, ARA administration significantly increased the plasma levels of ARA, prostaglandin (PG) E2, and PGD2.”
Effects of Long-Term Oral Administration of Arachidonic Acid and Docosahexaenoic Acid on the Immune Functions of Young Rats“Prior addition of either PGE2 (2.8 × 10−10 M) or arachidonic acid (2.8 × 10−7 M) inhibited or reversed various actions of PGD2 on the heart.”
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