supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago
supplement:
Arachidonic Acid
supplement:
Potassium
Research Papers that Mention the Interaction
“ Arachidonic acid partially inhibited potassium‐ and A23187‐evoked release but did not reverse the inhibition of potassium‐evoked release observed in the presence of RG 80267.”
Effect of Inhibitors of Eicosanoid Metabolism on Release of [3H]Noradrenaline from the Human Neuroblastoma, SH‐SY5Y“… potassium, AA (10-50 microM) increased total membrane current produced by either depolarizing or hyperpolarizing voltage steps delivered from a holding potential of -40 mV. Decreasing … reversal potential of the AA-induced current by 10 mV rather than the approximately 42 mV predicted for a highly potassium-selective channel.”
“Several observations suggest that arachidonic acid (AA) may be involved in overrecovery: (1) AA enhanced IM in a dose- dependent and reversible manner, with an IC50 of 2.8 microM. (2) Muscarine inhibited the A-current (IA), a potassium current that is blocked by AA. (”
On the role of arachidonic acid in M-current modulation by muscarine in bullfrog sympathetic neurons“Exposure of the inside surface of patches of membrane excised from cultured rat hippocampal neurons to arachidonic acid (10–100 μM) caused the appearance of potassium currents of variable amplitude similar to those activated by GABA or baclofen in cell-attached patches.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback