Possible Interaction: Arachidonic Acid and Phosphatidylethanolamine

“This suggests that phosphatidylethanolamine may be an important source of the released arachidonic acid.”

“A 15% decrease in arachidonic content was observed in the fatty acid composition of PE.”

“Prostaglandin synthase plus arachidonic acid significantly enhanced the ischemia-evoked release of all amino acids (aspartate 360 fold; glutamate 433 fold; glycine 6 fold; GABA 689 fold; phosphoethanolamine 69 fold) and increased the pre-ischemic levels of glutamate, glycine and phosphoethanolamine.”

“Treatment of rat liver cells (the C-9 cell line), porcine aorta endothelial cells, bovine aorta smooth …, mouse fibroblasts and rat keratinocytes with highly purified, crystallized Bacillus cereus phospholipase C, which hydrolyzes phosphatidylcholine, phosphatidylethanolamine and phosphatidylserine but has little or no …, lysophosphatidylcholine or lysophosphatidylethanolamine, increased metabolism of arachidonic acid.”

“They also show a decreased incorporation rate of arachidonic acid into PhC, PhE , and PhC plasmalogen and PhE plasmalogen.”

“Although there was no significant difference in the incorporation of radioactivity into the total phospholipid in either system, there was a large decrease in [3H]arachidonic acid incorporated into phosphatidylethanolamine and to a lesser extent phosphatidylcholine and phosphatidylinositol in persistently infected cells.”

“An inverse relationship between arachidonic acid content of phosphatidylcholine and phosphatidylethanolamine was observed.”

“In mitochondria from ethanol-fed animals, palmitic and arachidonic acid were lowered in phosphatidylcholine and phosphatidylethanolamine.”

“In the lecithins and phosphatidylethanolamines of the regenerating liver the content of arachidonic acid is lower and that of linoleic acid is higher than in the corresponding lipid fractions of normal rat liver.”