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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Phenytoin
Research Papers that Mention the Interaction
“Furthermore, recent evidence suggests that phenytoin disrupts craniofacial and neural tube morphogenesis by inhibiting the arachidonic acid cascade , a pathogenesis already implicated for glucocorticoids and hyperglycemia in the palate.”
“This study tested the hypothesis that phenytoin interferes with the arachidonic acid cascade via the same biochemical pathway demonstrated for glucocorticoids.”
Common biochemical pathway of dysmorphogenesis in murine embryos: use of the glucocorticoid pathway by phenytoin.“ Phenytoin significantly attenuated the accumulation of lactate and free fatty acids ( arachidonic acid and stearic acid) during ischemia and accelerated their recovery during recirculation.”
“Specimens cultured in DPH plus AA had significantly fewer defects in each of the three features than those treated with DPH alone.”
“These data support the hypothesis that phenytoin disrupts normal embryonic development through interruption of the arachidonic acid cascade.”
“We hypothesize that phenytoin disrupts craniofacial morphogenesis by inhibiting the arachidonic acid cascade ; a pathogenesis already demonstrated for glucocorticoids and hyperglycemia.”
“In this paper, we have investigated whether glucocorticoids and phenytoin inhibit arachidonic acid release and prostaglandin biosynthesis directly in the embryonic palates and whether the H-2 gene complex influences the degree of inhibition.”
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