Possible Interaction: Arachidonic Acid and Pancreatic Polypeptide

“At normal perfusion pressure (PP; 70 to 90 mm Hg), AA constricted the renal vasculature in both SHR and normotensive Wistar-Kyoto rats, an effect abolished by cyclooxygenase inhibition, and converted to vasodilation when PP was raised to ≈200 mm Hg.”

“Unexpectedly, … AA was greater … at high PP ; for example, 2.5, 5, and 10 &mgr;g of AA produced PP declines of 54±9, 92±10, and 112±…, respectively, in SHR compared with 26±3, 45±5, and 77±6 mm Hg in Wistar-Kyoto rats (P <0.01).”