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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
supplement:
Oxytocin
Research Papers that Mention the Interaction
“DHA and AA significantly inhibited phosphatidylinositol turnover and [Ca2+]i mobilization with oxytocin stimulation compared to bovine serum albumin control and equimolar oleic acid.”
“DHA and AA significantly reduced oxytocin receptor membrane concentration without altering binding affinity or rate of receptor internalization.”
Long Chain Polyunsaturated Fatty Acids Alter Oxytocin Signaling and Receptor Density in Cultured Pregnant Human Myometrial Smooth Muscle Cells“The TREK‐1 activator arachidonic acid reduced oxytocin contraction in preterm and term, singleton and twin pregnant uterus.”
“It is concluded that PGF2 alpha and oxytocin promote, by different mechanisms, the release of AA , which in turn may amplify their action by enhancing Ca2+ mobilization from the sarcoplasmic reticulum, thereby fulfilling the role of intracellular signaling molecule in human myometrium.”
“ Oxytocin also stimulated arachidonic acid release and prostaglandin E2 and F2 alpha production in gestational myometrium.”
“These results are consistent with the proposition that 5-LO products of arachidonic acid may modulate OT secretion from the ovine corpus luteum.”
Suppression of ovarian oxytocin secretion after intra-luteal administration of the arachidonate 5-lipoxygenase inhibitor BWA4C in the ewe.“When the endometrial cells were exposed to OT (0.1-1000 nM) in combination with arachidonic acid (10 microM), OT stimulated prostaglandin F2 alpha secretion in a dose-dependent manner.”
“ Arachidonic acid release and PGE2 synthesis were also stimulated by OT.”
“However, addition of arachidonic acid (100 microM) caused a significant increase in the secretion of PGF2 alpha and the specific binding for oxytocin concomitantly (P < 0.05).”
“ AA elicited a significant (P < ….05) release of OT from the large cells and P4 from both the large and small cells within 1 hr of incubation, having a … effect at a concentration of 10 μM. Larger doses (25 and 100 μM) of AA adversely affected the cell viability.”
“Lipoxygenase products of AA (hydroxyeicosatetraenoic acid and leukotrienes; 25 ng/ml) also stimulated OT release.”
“Release of oxytocin by sliced or minced sheep luteal tissue in vitro was stimulated up to 1.6- and 2.3-fold by arachidonic acid and the calcium ionophore A23187 respectively.”
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