Possible Interaction: Arachidonic Acid and Oleic Acid

“ AA and OA elicited a complex response marked by a general DNA hypermethylation and hypomethylation in the 1–200 μM range, respectively, with a maximal differential response at the 100 μM dose.”

“Arachidonic acid AA ), an n-6 polyunsaturated fatty acid, is a precursor of the proinflammatory cytokines prostaglandin E2 and leukotriene B4, and its metabolism is competitively inhibited by oleic acid (OA).”

“ConclusionsIn a group of healthy human subjects, percentages of oleic acid and arachidonic acid were inversely related, and the inverse association persisted when controlling for possible confounding variables.”

“The addition of eicosatetraynoic acid , which inhibits delta-6 desaturase activity which is inherently high in HepG2 cells, led to a marked accumulation of oleic and palmitoleic acids in the core-expressing cells, showing that delta-9 desaturase was activated by the core protein.”

“The analyses show that palmitic- and oleic acid sites of transport are entirely independent but do not exclude that palmitic- and/or oleic acid binding may diminish the arachidonic acid affinity a little.”

“Ratios between oleic and arachidonic acid and between eicosatrienoic and arachidonic acids were also significantly higher in the dialysis group.”

“Conversion of arachidonic acid to thromboxane B2 was increased during 10 min in the presence of oleic , alpha-linolenic and lauric acids.”

“The splanchnic fractional uptake for arachidonic acid significantly exceeded that for oleic acid at rest.”

“ Arachidonic acid increased the rate of reactive oxygen species (ROS) production, while oleic acid decreased it.”

“An additional stimulation of the swelling-activated taurine efflux is seen after addition of arachidonic acid and oleic acid.”