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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Norepinephrine
Research Papers that Mention the Interaction
“In veins, however, the endothelium-dependent inhibitory effect of acetylcholine, ATP, and thrombin often is transient and/or modest, as it is masked by the direct stimulating action of these substances on the venous smooth muscle; arachidonic acid evokes endothelium-dependent augmentation of the contractile response to norepinephrine.”
Heterogeneity of Endothelium‐Dependent Responses in Mammalian Blood Vessels“Release of arachidonic acid by Ca2+ ions was inhibited by 30%-50% in the presence of 10(-4) M dibutyryl-cAMP (Bt2cAMP), isoproterenol, or noradrenaline.”
“Namely, the Ω-6 arachidonic and linoleic acids, based on their effect on CA release and cellular content, seemed to impair NA and AD vesicular transport, whereas γ-linolenic acid selectively impaired AD synthesis and release.”
Dietary unsaturated fatty acids differently affect catecholamine handling by adrenal chromaffin cells.“ AA also increased the turnover of dopamine (DA), noradrenaline ( NA ), and serotonin (5-HT) in the amygdala and increased the prostaglandin (PG)E(2) level in the hippocampus.”
“Similarly, chronic norepinephrine treatment in rats resulted in a net decrease in linoleic acid and an increase in arachidonic acid and docosahexaenoic acid, which was particularly pronounced when rats were fed an n-3 polyunsaturated fatty acid (PUFA)-rich oil diet.”
“Summary: Noradrenaline‐induced contraction of the rat coronary arteries was significantly augmented by the presence of NG‐nitro‐ L‐arginine methyl ester (L‐NAME) and arachidonic acid.”
“LOE 908, a receptor-operated Ca(2+) channel blocker, inhibited the sustained increase in [Ca(2+)](i) and inward currents in a concentration-dependent manner, and complete inhibition was observed at concentrations > or = 3 microM. NA induced arachidonic acid release in all three cell types.”
“ Norepinephrine stimulates release of arachidonic acid from tissue lipids.”
“The inhibitor of all the pathways of AA metabolism, 10 microM eicosatetraynoic acid (ETYA), reduced the constrictor responses to all the concentrations of NA assayed.”
“Perhaps arachidonic acid extends the effect of NE on one specific smooth muscle cell to its nearby neighbor cells.”
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