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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Nitric Oxide
Research Papers that Mention the Interaction
“This cis-trans isomerization is biologically relevant because many pathologies that involve NO formation such as inflammation, hyperoxia, hypercapnia or exposure to cigarette smoke increase the TAA levels in cells, tissues and in the systemic circulation.”
Trans-arachidonic acids: new mediators of nitro-oxidative stress.“Moreover, AA caused an increase in NO levels which was blocked by preventing the concomitant increase in [Ca2+]i and by inhibiting eNOS activity with NG-nitro-l-arginine methyl ester (l-NAME).”
“ Arachidonic acid dose-dependently reduced NO and cGMP level.”
“Likely arachidonic acid reducing NO bioavailability through all these mechanisms could potentiate its platelet aggregating power.”
“Arachidonic acid AA ), which is increased in the serum and airways of CF patients, has been shown to reduce NO levels.”
“These effects of AA were associated with significant decreases in the cellular consumption of D-glucose and L-alanine as well as decreased rates of production of nitric oxide and ammonia.”
“When NO is transformed into a nitrating and nitrosating species, it has been shown to react with unsaturated lipids.3,4⇓ Recently, such nitrated lipids have been demonstrated to be formed in vivo.5 The oxidation product of NO , NO2, has been shown to react with arachidonic acid generating …”
“In control and cirrhotic HEC, COX activation with arachidonic acid reduced NO bioavailability and increased O2− levels.”
Interaction between NO and COX pathways modulating hepatic endothelial cells from control and cirrhotic rats“These results suggest that NO affects the intracellular level of AA through alteration of cPLA2 and AA-CoA acyltransferase activities and may have an important implication in alterations of nerve endings properties and function.”
“ Nitric oxide may act as a modulator of the arachidonic acid cascade and in the generation of oxygen-active species.”
“ AA concentration-dependently inhibited the effects of carbachol in producing NO (IC50 = 191 μM) but did not alter inositol phosphate production or M1 receptor binding.”
“Strong evidence supports that nitric oxide (NO) alters cell signaling pathways involving arachidonic acid (AA).”
“These data support the concept that AA concentration-dependently inhibits receptor-mediated NO production at the level of calcium mobilization.”
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