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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Nimesulide
Research Papers that Mention the Interaction
“It is concluded that an increase in intracellular cAMP is instrumental in the observed effects … the release of PAF and LTB4 by activated neutrophils and that limited availability of arachidonic acid , also the substrate for the cyclooxygenase … well contribute to the effects of nimesulide on prostaglandin synthesis … cell types.”
Inhibition of the production of platelet activating factor and of leukotriene B4 in activated neutrophils by nimesulide due to an elevation of intracellular cyclic adenosine monophosphate.
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