Possible Interaction: Arachidonic Acid and Nifedipine

“Upregulation of CYP2C expression by preincubation with nifedipine enhanced the responses to AA and cell swelling in wild-type MAECs, whereas responses to other stimuli remained unaffected.”

“The contractile response to arachidonic acid was inhibited by both nifedipine (1 µM) and SKF 96365 (30 µM) (83±5 and 79±3% inhibition, respectively).”

“Inhibition of voltage-dependent Ca++ channels with nifedipine (5 nM) attenuated vasodilation to anandamide and arachidonic acid whereas inhibition of Ca++-activated K+ channels with charybdotoxin (10 nM) reduced responses to arachidonic acid but had no effect on vasodilation induced by anandamide.”

“alpha 1-AR-stimulated arachidonic acid release was dependent upon extracellular calcium and was inhibited by 1 microM nifedipine.”

“The results indicate that (1) endothelial cells spontaneously secrete thromboxane A2, (2) this production can be enhanced severalfold in the presence of arachidonic acid , and (3) the calcium-channel blocker nifedipine significantly inhibits thromboxane production without demonstrable toxicity to the endothelial cells.”

“The calcium channel blockers nifedipine and verapamil inhibited release of arachidonic acid only.”

“At a dose of 500 μg/kg, nifedipine inhibited thrombotic sudden death provoked by arachidonic acid , a thromboxane agonist (U46619), or a combination of collagen and epinephrine.”

“Several different calcium entry blocking drugs had a partial inhibitory effect on the NE response, but it was noted that the dihydropyridine derivatives, nifedipine and nimodipine, also decreased the stimulatory effect of added exogenous arachidonic acid (AA).”