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Last Updated: 2 years ago

Possible Interaction: Arachidonic Acid and Nifedipine

Research Papers that Mention the Interaction

Upregulation of CYP2C expression by preincubation with nifedipine enhanced the responses to AA and cell swelling in wild-type MAECs, whereas responses to other stimuli remained unaffected.
Circulation research  •  2005  |  View Paper
The contractile response to arachidonic acid was inhibited by both nifedipine (1 µM) and SKF 96365 (30 µM) (83±5 and 79±3% inhibition, respectively).
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2000  |  View Paper
Inhibition of voltage-dependent Ca++ channels with nifedipine (5 nM) attenuated vasodilation to anandamide and arachidonic acid whereas inhibition of Ca++-activated K+ channels with charybdotoxin (10 nM) reduced responses to arachidonic acid but had no effect on vasodilation induced by anandamide.
The Journal of pharmacology and experimental therapeutics  •  1998  |  View Paper
alpha 1-AR-stimulated arachidonic acid release was dependent upon extracellular calcium and was inhibited by 1 microM nifedipine.
Molecular pharmacology  •  1993  |  View Paper
The results indicate that (1) endothelial cells spontaneously secrete thromboxane A2, (2) this production can be enhanced severalfold in the presence of arachidonic acid , and (3) the calcium-channel blocker nifedipine significantly inhibits thromboxane production without demonstrable toxicity to the endothelial cells.
The Annals of thoracic surgery  •  1990  |  View Paper
The calcium channel blockers nifedipine and verapamil inhibited release of arachidonic acid only.
Journal of neurochemistry  •  1990  |  View Paper
At a dose of 500 μg/kg, nifedipine inhibited thrombotic sudden death provoked by arachidonic acid , a thromboxane agonist (U46619), or a combination of collagen and epinephrine.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine  •  1986  |  View Paper
Several different calcium entry blocking drugs had a partial inhibitory effect on the NE response, but it was noted that the dihydropyridine derivatives, nifedipine and nimodipine, also decreased the stimulatory effect of added exogenous arachidonic acid (AA).
Prostaglandins, leukotrienes, and medicine  •  1985  |  View Paper