supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Arachidonic Acid
Research Papers that Mention the Interaction
“ AA decreased cell viability from 100% to 48+/-6% after treatment for 48 h. In the presence of L-NAME , viability was further lowered to 23+/-5%, while, SNAP or DETA-NONO increased viability to 66+/-8 or 71+/-6%.”
Nitric oxide donors prevent while the nitric oxide synthase inhibitor L-NAME increases arachidonic acid plus CYP2E1-dependent toxicity.“Moreover, AA caused an increase in NO levels which was blocked by preventing the concomitant increase in [Ca2+]i and by inhibiting eNOS activity with NG-nitro-l-arginine methyl ester (l-NAME).”
“The inhibition of gp120-induced PGE2 production by L-NAME was reverted by addition of arachidonic acid (30 microM), an effect antagonized by the cyclo-oxygenase inhibitor indomethacin (10 microM).”
“Treatment of diabetic rats with L-NAME reduced arachidonic acid-stimulated release of prostaglandins and the expression of COX-2.”
Effect of inhibition of nitric oxide synthase on renal cyclooxygenase in the diabetic rat.“Our results demonstrated …) highly increased [3H]arachidonic acid output, while S-nitroso-N-acetylpenicillamine (SNAP) was without effect; (c) AACOCF(3) completely blocked the [3H]arachidonic acid release … acid output was also increased by L-arginine; (f) a similar effect was, paradoxically, obtained in the presence of L-NAME.”
“ Arachidonic acid increased blood flow, which was inhibited by indomethacin, L-NAME , or the PGD2-receptor antagonist BW-A868C.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback