Possible Interaction: Arachidonic Acid and Neuromuscular Depolarizing Agents

“ Arachidonic acid increased the currents at lower depolarizing potentials, while it suppressed the currents at higher depolarizing potentials and at less negative holding potentials.”

“Second, AA caused a marked acceleration of current decay, thereby reducing IK amplitude measured toward the end of the depolarizing steps.”

“In a … potassium, AA (10-… either depolarizing or hyperpolarizing voltage steps delivered from a holding potential of -40 mV. Decreasing the external potassium concentration from 12.5 to … of the AA-induced current by 10 mV rather than the approximately 42 mV predicted for a highly potassium-selective channel.”

“Incubation in a depolarizing medium (45 mM K+) resulted in a selective increase in hydroxyeicosatetraenoic acids, an effect that was blocked by nordihydroguaiaretic acid (1 microM) and eicosatetraynoic acid (10 microM).”