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“Ethanolamine glycerophospholipid synthesis was elevated during differentiation induced by nerve growth factor and it was suppressed by added arachidonic acid but not by docosahexaenoic acid.”
“In addition, a 12h treatment with nicotine increased mRNA levels of trkA. Both nicotine and exogenous NGF inhibited arachidonic acid induced apoptosis of spinal cord neurons.”
“Our results also suggest that AA , an inflammatory signal lipid induced by TNFα via binding to TNFR‐I, may reduce neuronal survival by inhibiting elements of the signal cascade induced by NGF.”