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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Arachidonic Acid
drug:
Neomycin
Research Papers that Mention the Interaction
“In the presence of either quinacrine, an inhibitor of PLA2 pathway activation, or neomycin , which binds to PI mono- and biphosphate thus blocking their degradation by phospholipases, AA and PGE2 secretion were reduced in a dose-dependent manner.”
Interleukin-1-mediated phospholipid breakdown and arachidonic acid release in human synovial cells.“Moreover, neomycin enhanced arachidonic acid release induced by thrombin.”
“Moreover, treatment of cells with neomycin failed to attenuate rbFGF-mediated release of [3H]arachidonic acid.”
Stimulation of arachidonic-acid release from Swiss 3T3 cells by recombinant basic fibroblast growth factor: independence from phosphoinositide turnover.“ Neomycin (1 mM) also reversed GTP gamma S-stimulated, but not calcium-stimulated release of arachidonic acid.”
“The ability of 1 mM neomycin to inhibit arachidonic acid release was reversed by addition of 1 microM phorbol 12-myristate 13-acetate, implying a role for protein kinase C activation in stimulation of arachidonic acid release.”
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