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Discover Supplement-Drug Interactions

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Last Updated: 6 months ago

Possible Interaction: Arachidonic Acid and Muscarinic Agonists

Research Papers that Mention the Interaction

Muscarinic agonists stimulated arachidonic acid release from 10- to 32-fold in Chinese hamster ovary (CHO) cells transfected with muscarinic M1, M3 and M5 receptor subtypes.
Cellular signalling  •  1999  |  View Paper
Insulin secretagogues, such as glucose and the muscarinic agonist carbachol, stimulate arachidonic acid accumulation, although the mechanisms involved are controversial: carbachol is believed to stimulate phospholipase A2, while glucose-induced arachidonic acid release is the result of diacylglycerol hydrolysis [Konrad, R. J., et al. (1992) Biochem.
Biochemistry  •  1993  |  View Paper
We conclude that muscarinic receptor agonists rapidly induce specific changes in arachidonic acid and phosphatidic acid metabolism in a glioma cell line and suggest that similar responses may occur in glial cells and play a physiologically significant role in neural metabolism.
The Journal of biological chemistry  •  1986  |  View Paper