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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Miconazole
Research Papers that Mention the Interaction
“In rat coronary arteries that produce PGI(2) as the major arachidonic acid (AA) metabolite, activation of the large-conductance K(+) (BK) channels in coronary arterial smooth muscle cells by AA was inhibited by miconazole but not by the CYP inhibitor SKF525A.”
Inhibition of PGI2 signaling by miconazole in vascular smooth muscle cells.“However, inhibition of epoxygenase with miconazole caused a significant reduction in the response to ET-1 and to AA , without affecting neither basal pressure nor the response to PE.”
11,12-EET increases porto-sinusoidal resistance and may play a role in endothelial dysfunction of portal hypertension.“ Miconazole inhibited conversion of AA to EETs by cultured astrocytes but had no effect on the conversion of L-arginine to L-citrulline by homogenates of rat brain.”
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