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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Metyrapone
Research Papers that Mention the Interaction
“ Metyrapone and SKF-525A, together with amphenone B, a structural analogue of metyrapone, which are all inhibitors of cytochrome P-450-mediated reactions, were shown to inhibit the arachidonic acid-induced aggregation of human platelets.”
Comparison of the effects of inhibitors of cytochrome P-450-mediated reactions on human platelet aggregation and arachidonic acid metabolism.“ Metyrapone and carbon monoxide (CO), two inhibitors of cytochrome P-450, inhibited both the arachidonic acid-induced platelet aggregation and the formation of aggregating factors from arachidonic acid by isolated microsomes.”
“Exposure of cultured cortical neurons to AA (50 μM) yielded significantly apoptotic neuronal death, which was attenuated greatly by LOX inhibitors (nordihydroguaiaretic acid, AA861, and baicalein), or CYP450 inhibitors (SKF525A and metyrapone ), rather than COX inhibitors (indomethacin and NS398).”
Arachidonic acid induces neuronal death through lipoxygenase and cytochrome P450 rather than cyclooxygenase“In contrast, the cytochrome P-450 epoxygenase inhibitors, SKF525A and metyrapone , substantially reduced arachidonic acid-induced recovery of growth while having minimal effects on control cell growth.”
“2 Metyrapone and indomethacin administered in vitro both inhibited the conversion of 14C‐arachidonic acid to prostaglandin E2 by homogenates of day 22 pregnant rat uteri.”
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