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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Methylene Blue
Research Papers that Mention the Interaction
“Treating cells with either methylene blue (20 μm) or the cyclo‐oxygenase inhibitor, flurbiprofen (10 μm), inhibited both resting and arachidonic acid (1 μm)‐induced production of 6‐keto‐PGF1α.”
Methylene blue but not changes in cyclic GMP inhibits resting and bradykinin‐stimulated production of prostacyclin by pig aortic endothelial cells“In an attempt to elucidate the mechanisms of these responses, we found that preincubation with methylene blue , an inhibitor of soluble guanylate cyclase activity, inhibited both Ach and AA induced relaxation.”
“Basal, arachidonic acid (10(-5) M)-stimulated, and nitroprusside (5 X 10(-5) M)-stimulated guanylate cyclase activities were inhibited by methylene blue and the lipoxygenase inhibitors nordihydroguaiaretic acid and eicosatetraynoic acid.”
“Indomethacin partially inhibited endothelium-dependent relaxation and abolished cyclic AMP accumulation whereas methylene blue , a guanylate cyclase inhibitor, partially inhibited relaxation and abolished cyclic GMP accumulation in response to arachidonic acid.”
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