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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Mefenamic Acid
Research Papers that Mention the Interaction
“Ibuprofen and mefenamic acid are weak, competitive inhibitors of cyclooxygenase-2 (COX-2) oxygenation of arachidonic acid (AA) but potent, noncompetitive inhibitors of 2-arachidonoylglycerol (2-AG) oxygenation.”
Differential Sensitivity and Mechanism of Inhibition of COX-2 Oxygenation of Arachidonic Acid and 2-Arachidonoylglycerol by Ibuprofen and Mefenamic Acid†“Furthermore, the activation of current induced by intracellular application of mefenamic acid was mimicked by other cyclooxygenase inhibitors and arachidonic acid.”
“Three nonsteroidal antiinflammatory agents--indomethacin, aspirin, and mefenamic acid --that inhibit the cyclooxygenase-dependent conversion of arachidonic acid to PGs reduced most aspects of dysfunction associated with reperfusion.”
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