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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Meclofenamate
Research Papers that Mention the Interaction
“ Meclofenamate successfully blocked the conversion of arachidonic acid to vasoconstrictive eicosanoids such as TxA(2); nevertheless, meclofenamate failed to inhibit PH in response to LPS.”
Broiler pulmonary hypertensive responses during lipopolysaccharide-induced tolerance and cyclooxygenase inhibition.“In ex vivo assays, meclofenamate , but not nimesulide, prevented the platelet aggregation elicited by arachidonic acid.”
“The cyclooxygenase inhibitor meclofenamate (3 x 10(-5) M superfusate concentration) completely abolished the dilator responses to topically applied arachidonic acid , but had no effect on the magnitude or rate of sympathetic constriction in any vessel type.”
“Vasodilator responses to pentoxifylline and acetylcholine were not significantly changed in the presence of meclofenamate, whereas meclofenamate markedly reduced the vasopressor effects of arachidonic acid.”
“ Meclofenamate abolished both dilator and constrictor actions of arachidonic acid ; it raised baseline, normoxic pulmonary artery pressure, in chronically hypoxic but not control rats, which suggests that dilator products of arachidonic acid are released in the pulmonary hypertension of chronic hypoxia and attenuate pulmonary artery pressure.”
“ Meclofenamate (10(-5) M) blocked the increased metabolite synthesis over the entire dose range of arachidonic acid tested (7.5 ng-75 micrograms).”
“However, the cyclooxygenase inhibitor indomethacin (or meclofenamate ), which completely blocked the dilator response to arachidonic acid but did not change the response to acetylcholine, inhibited the arteriolar dilation (mean increase, 0.3 +/- 0.2 micron) due to increases in red blood cell velocity (9.3 +/- 1.0 mm/sec).”
“2 Inhibition of cyclo‐oxygenase with indomethacin or meclofenamate reduced the renal vasoconstrictor effect of arachidonic acid.”
“Cyclo-oxygenase was inhibited by infusion of meclofenamate (60 micrograms X min-1) which consistently abolished the vasodilator responses to arachidonic acid added to the donor.”
“The vasodilatory effect of arachidonic acid but not acetylcholine was blocked by meclofenamate.”
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