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Possible Interaction: Arachidonic Acid and Meclofenamate Sodium

Research Papers that Mention the Interaction

Meclofenamate successfully blocked the conversion of arachidonic acid to vasoconstrictive eicosanoids such as TxA(2); nevertheless, meclofenamate failed to inhibit PH in response to LPS.
Poultry science  •  2009  |  View Paper
Meclofenamate sodium was compared to other nonsteroidal antiinflammatory drugs in terms of its potency to inhibit the formation of 5-HETE and LTB4 in … of prostaglandin E2 in bovine seminal vesicles as measures of its ability to inhibit the 5-lipoxygenase and cyclooxygenase pathways of the arachidonic acid cascade.
Meclofenamate sodium , like BW-755C, can be considered a dual inhibitor of 5-lipoxygenase and cyclooxygenase pathways of arachidonic acid cascade.
Prostaglandins, leukotrienes, and medicine  •  1986  |  View Paper
In ex vivo assays, meclofenamate , but not nimesulide, prevented the platelet aggregation elicited by arachidonic acid.
Hypertension  •  2000  |  View Paper
Meclofenamate significantly reduced vasodilator responses to arachidonic acid without effecting responses to propofol.
Acta anaesthesiologica Scandinavica  •  1999  |  View Paper
Vasodilator responses to pentoxifylline and acetylcholine were not significantly changed in the presence of meclofenamate, whereas meclofenamate markedly reduced the vasopressor effects of arachidonic acid.
Critical care medicine  •  1996  |  View Paper
Infusion of sodium meclofenamate abolished the effect of AA to increase 6-keto-PGF1 alpha and to decrease glycerol output.
The American journal of physiology  •  1996  |  View Paper
It also is suggested that the nonsteroidal anti-inflammatory compound, meclofenamate , may interfere with the binding of another (non-cyclooxygenase) product of arachidonic acid metabolism.
The Journal of pharmacology and experimental therapeutics  •  1993  |  View Paper
Meclofenamate abolished both dilator and constrictor actions of arachidonic acid ; it raised baseline, normoxic pulmonary artery pressure, in chronically hypoxic but not control rats, which suggests that dilator products of arachidonic acid are released in the pulmonary hypertension of chronic hypoxia and attenuate pulmonary artery pressure.
The European respiratory journal  •  1993  |  View Paper
Meclofenamate (10(-5) M) blocked the increased metabolite synthesis over the entire dose range of arachidonic acid tested (7.5 ng-75 micrograms).
Journal of applied physiology  •  1990  |  View Paper
However, the cyclooxygenase inhibitor indomethacin (or meclofenamate ), which completely blocked the dilator response to arachidonic acid but did not change the response to acetylcholine, inhibited the arteriolar dilation (mean increase, 0.3 +/- 0.2 micron) due to increases in red blood cell velocity (9.3 +/- 1.0 mm/sec).
Circulation research  •  1990  |  View Paper
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