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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Arachidonic Acid and Mecamylamine

Research Papers that Mention the Interaction

Mecamylamine (a non-specific antagonist of nAChRs) and alpha-bungarotoxin (a specific antagonist of the nAChRalpha7) completely inhibited nicotine-mediated protection against arachidonic acid-induced alterations of BDNF and FGF-2.
Journal of neurotrauma  •  2003  |  View Paper
Furthermore, arachidonic acid induced a long-lasting (>/=3 h) facilitation of hippocampal CA1 synaptic transmission in slices, and the effect was blocked by nicotinic ACh receptor antagonists, alpha-bungarotoxin and mecamylamine.
Brain research. Molecular brain research  •  1999  |  View Paper