Possible Interaction: Arachidonic Acid and Masoprocol

“ Nordihydroguaiaretic acid , an inhibitor of the lipoxygenase pathway, significantly inhibited both hydrogen peroxide and arachidonic acid-stimulated c-Fos and c-Jun protein expression and AP-1 activity.”

“A LOX inhibitor, nordihydroguaiaretic acid , attenuated production of 15(S)-HETE and inhibited the phosphorylation of p38 MAPK following exposure to arachidonic acid.”

“The ability of arachidonic acid to stimulate PI3K activity in neutrophils was suppressed by indomethacin and nordihydroguaiaretic acid , inhibitors of the cyclooxygenases and lipoxygenases, respectively, but not by 17-octadecynoic acid, an inhibitor of ω-hydroxylation of arachidonic acid by cytochrome P450 monooxygenases.”

“Esculetin and nordihydroguaiaretic acid inhibited formation of hepoxilin B3, 12-oxo-eicosatetraenoic acid , trioxilins, and 12-hydroxyeicosatetraenoic acid in a concentration-dependent manner.”

“In contrast, the increase in adhesion to vitronectin induced by A23187 and AA was, at best, only partially inhibited by nordihydroguaiaretic acid treatment.”

“The increased rate in NNK oxidation by arachidonic acid or lipoxygenase was inhibited completely by nordihydroguaiaretic acid.”

“The arachidonic acid uptake activity was significantly reduced by the presence of indomethacin in platelets obtained from both under and over-forty year old subjects, and by the presence of nordihydroguaiaretic acid in platelets obtained from over-forty year old subjects.”

“Pretreatment of LAN‐5 cells with nordihydroguaiaretic acid , a lipoxygenase inhibitor, or with indomethacin, a cyclooxygenase inhibitor, amplified the release of[3H]arachidonic acid and production of lysophosphatidylcholine induced by non‐saturating concentrations of IFN‐γ.”

“For example, NDGA inhibited arachidonic acid-stimulated release with a 50% inhibitory concentration (IC50) of 0.39 microM for PGI2, 0.25 microM for 15-HETE, and 0.10 microM for 12-HETE.”

“ Nordihydroguaiaretic acid and 5,8,11,14-eicosatetraynoic acid both inhibited the conversion of arachidonic acid to 15-HETE with respective 50% inhibitory concentrations of 2.0 microM and 0.9 microM, while ATP, GTP, and cyclic AMP had no effect on activity at pH 6.8-7.2.”