Possible Interaction: Arachidonic Acid and Linolenic Acid

“The diet high in α-linolenic acid (p < 0.05) decreased the arachidonic acid (C20:4n-6) and conjugated linolenic acid (CLA) c-9 t-11 content in the ST muscle.”

“Protective associations were observed between intakes of ALA (P-trend = 0.02) and hip fracture risk in a combined sample of women and men and between intakes of AA (P-trend = 0.05) and hip fracture risk in men only.”

“… AA ) lowered their activation threshold, accelerated the activation kinetics and increased the open probability with a half-maximal concentration of about … effect correlated with the number of double bonds (db) in the fatty acids, increasing from oleic acid (1 db), linolenic acid (3 db), AA (4 … acid (5 db).”

“In addition to its own direct preventive effect on cardiac arrhythmias, dietary ALA actually inhibits the elongation and desaturation of linoleic acid (18:2 n-6) into arachidonic acid.”

“ α-LNA and its desaturation/elongation products, eicosapentaenoic acid (EPA) and DHA, may play an important role in modulating the synthesis of arachidonic acid (AA), prostanoids, leukotrienes (LTs), and various bioactive hydroxy fatty acids.”

“While ARA, EPA and DHA each stimulated the production of oxylipins derived from these fatty acids themselves, ARA also stimulated the production of oxylipins from endogenous 18- and 20-carbon fatty acids, including α-linolenic acid.”

“Arachidic acid was without effect, while linoleic acid and linolenic acid were (on a concentration basis) at least 5‐times less active than arachidonic acid.”

“Dietary supplementation of α-linolenic acid resulted in higher (P < 0.05) α-linolenic acid and EPA concentrations in liver and adipose tissue and lower (P < 0.05) arachidonic acid in liver, adipose tissue and brain compared with mice that did not receive α-linolenic acid.”

“ AA content in the tissue increased significantly (P < 0.001) with increasing dietary LA in both all chicken tissues and all turkey tissues, which is contrary to the suggested strong metabolic regulation of the AA formation.”

“Our results suggest that alpha-linolenic acid affectively suppressed the indomethacin-induced decreases in gastric mucosal blood flow by increasing EPA and decreasing the levels of arachidonic acid and LTC4 in the gastric mucosa.”