Possible Interaction: Arachidonic Acid and Linoleic Acid

“We also provide suggestions regarding dietary measures that are able to prevent an imbalance between arachidonic acid and its parental compound linoleic acid , in order to counteract the inflammatory state which characterizes numerous kidney diseases.”

“Recent findings In animal models, lowering dietary ARA or linoleic acid generally lowers levels of brain ARA and raises DHA.”

“The (log) ratio of linoleic to arachidonic acid was negatively related to scores (r=-0.45 to -0.48).”

“ Linoleic acid supplementation increased arachidonic acid levels in CF but not WT cells.”

“cftr(-/-) Mice supplemented with 100 mg of linoleic acid had increased arachidonic acid levels in lung tissue associated with increased neutrophil infiltration into the airway compared with control mice.”

“ Linoleic acid (LA, 18:2n-6) has variously been found to increase or inhibit synthesis of 2-series prostaglandins (PGs), derived from arachidonic acid (AA, 20:4n-6).”

“In humans who ingest 0.2-0.3 g of AA and 10-20 g of LA per day on a Western diet, the formation of AA from LA exceeds the dietary supply of AA.”

“On the basis of such slender evidence, huge edifices of antagonism to AA and LA have been erected.”

“The increased consumption of linoleic acid leads to higher levels of arachidonic acid and PGE2 as this fatty acid is their precursor.”

“Additionally, LA :DHA ratio was decreased in the ARA :DHA-S compared to control group (ARA:DHA-S = 6.26 ± 2.35, MCT-S = 8.21 ± 2.65; p = 0.045).”

“The amount of oleic acid (the main constituent of olive oil) provided in … g per day vs. 19 g per day),1 and the amount of linoleic acid, … arachidonic acid , corresponds to less than 5% of the normal daily intake (… expect such small relative changes to affect disease risk.”