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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Leukotriene C4
Research Papers that Mention the Interaction
“As arachidonic acid was found to be capable of inducing a fast, transient rise in the cytosolic free Ca2+ concentration, this explains, at least partly, its ability to induce the Ca2+-dependent formation of LTC4.”
Leukotriene C4 formation by purified human eosinophils can be induced by arachidonic acid in the absence of calcium-inophore A23187“At 10 micrograms/ml of AA , both LTC4 and LTB4 generation significantly increased to 114.2 +/- 5.3% and 129.0 +/- 9.5% of control, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)”
“Inhibitors of arachidonic acid metabolic pathways prevented the release of LTC4 and PGD2 from mast cells activated with antigen and IL‐1.”
“As arachidonic acid was found to be capable of inducing a fast, transient rise in the cytosolic free Ca2+ concentration, this explains at least partly its ability to induce the Ca2+-dependent formation of leukotriene C4.”
“ LTC4 prolonged the lag phase between addition of arachidonic acid and onset of aggregation.”
“Measurement of LTC4 by radioimmunoassay showed that there was a significant increase in LTC4 synthesis at 15 min after AA treatment.”
Correlation between mouse skin inflammation induced by arachidonic acid and eicosanoid synthesis“In addition, the accumulation of LTC4 and B4 in brain slices incubated in the presence of the Ca++ ionophore A23187 and arachidonic acid , was reduced in samples obtained from pretreated rats.”
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