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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Ketoconazole
Research Papers that Mention the Interaction
“This study demonstrates that ketoconazole is a comparatively specific and orally active inhibitor of the 5-lipoxygenase activity bearing on the production of leukotrienes derived from arachidonic acid.”
Ketoconazole inhibits the biosynthesis of leukotrienes in vitro and in vivo.“ Arachidonic acid also elicited a [Ca2+]i transient that was attenuated by ketoconazole.”
An epoxygenase metabolite of arachidonic acid mediates angiotensin II-induced rises in cytosolic calcium in rabbit proximal tubule epithelial cells.
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