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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Isoproterenol
Research Papers that Mention the Interaction
“ Isoproterenol and PGE2 appear thus to enhance arachidonic acid-induced platelet aggregation after interacting with different receptor sites.”
“ Isoproterenol potentiated aggregation due to sub-threshold amounts of arachidonic acid , and this effect, but not that due to PGE2, was suppressed by the α-blocking agents.”
Substances that increase the cyclic AMP content prevent platelet aggregation and the concurrent release of pharmacologically active substances evoked by arachidonic acid“Release of arachidonic acid by Ca2+ ions was inhibited by 30%-50% in the presence of 10(-4) M dibutyryl-cAMP (Bt2cAMP), isoproterenol , or noradrenaline.”
“The intrinsic efficacy of isoproterenol in inhibiting anti-IgE-induced release of arachidonic acid metabolites is approximately 3 times greater than that for inhibiting histamine release.(ABSTRACT TRUNCATED AT 250 WORDS)”
“ Isoproterenol also significantly increased the rate of arachidonic production in GH3 cells.”
Activation of BK channels in GH3 cells by a c-PLA2-dependent G-protein signaling pathway.“A further action of 10 μM AA was to suppress spontaneous electrical activity induced by either the β‐adrenergic agonist isoprenaline or the Na+ pump inhibitor, ouabain.”
“Incubation of detrusor strips with ETYA (7 or 14 microM) for 60 min significantly reduced tissue response to isoprenaline by an extent similar to that induced by indomethacin, but only slightly affected basal tone.”
“The inhibitory effect of AA on the isoprenaline‐ or cAMP‐stimulated ICa,L is largely reduced in cells internally perfused with the thiophosphate donor analogue of ATP, ATP gamma S, or protein phosphatase 1 and 2A inhibitors like microcystin (MC) or okadaic acid (OA).”
“Chronic administration of isoproterenol induced decreases of this enzyme activity and the content of arachidonic , bishomo-gamma-linolenic and 5,8,11,14,17-eicosapentaenoic acids at the sn-2 position of phosphatidylinositol.”
“ Isoproterenol (8 ng.ml-1.min-1) attenuated the arachidonic acid (4 mg)-induced increases in fluid flux, wet-to-dry weight ratio, albumin clearance, and PS and the decrease in sigma.”
“With AA present as well as INDO and NDGA, the transient and sustained responses to ISO were significantly reduced to 13.2 +/- 2.4 and 3.9 +/- 0.8 muA/cm2 (n = 10), respectively; the increase in cAMP was unaltered.”
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